| RRC ID |
2276
|
| 著者 |
Gründemann C, Bauer M, Schweier O, von Oppen N, Lässing U, Saudan P, Becker KF, Karp K, Hanke T, Bachmann MF, Pircher H.
|
| タイトル |
Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1.
|
| ジャーナル |
J Immunol
|
| Abstract |
The killer cell lectin-like receptor G1 (KLRG1) is expressed by NK cells and by T cells. In both humans and mice, KLRG1 identifies Ag-experienced T cells that are impaired in their proliferative capacity but are capable of performing effector functions. In this study, we identified E-cadherin as a ligand for murine KLRG1 by using fluorescently labeled, soluble tetrameric complexes of the extracellular domain of the murine KLRG1 molecule as staining reagents in expression cloning. Ectopic expression of E-cadherin in B16.BL6 target cells did not affect cell-mediated lysis by lymphokine-activated NK cells and by CD8 T cells but inhibited Ag-induced proliferation and induction of cytolytic activity of CD8 T cells. E-cadherin is expressed by normal epithelial cells, Langerhans cells, and keratinocytes and is usually down-regulated on metastatic cancer cells. KLRG1 ligation by E-cadherin in healthy tissue may thus exert an inhibitory effect on primed T cells.
|
| 巻・号 |
176(3)
|
| ページ |
1311-5
|
| 公開日 |
2006-2-1
|
| DOI |
10.4049/jimmunol.176.3.1311
|
| PII |
176/3/1311
|
| PMID |
16424155
|
| MeSH |
Animals
Antigens / immunology
CD8-Positive T-Lymphocytes / cytology
CD8-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / metabolism
Cadherins / biosynthesis
Cadherins / metabolism*
Cadherins / physiology
Cell Division / immunology
Cell Line
Growth Inhibitors / biosynthesis
Growth Inhibitors / metabolism
Growth Inhibitors / physiology
Killer Cells, Lymphokine-Activated / immunology
Killer Cells, Lymphokine-Activated / metabolism
Lectins, C-Type
Ligands
Melanoma, Experimental
Mice
Mice, Inbred C57BL
Mice, Transgenic
Receptors, Immunologic / genetics
Receptors, Immunologic / metabolism*
|
| IF |
4.886
|
| 引用数 |
105
|
|
WOS 分野
|
IMMUNOLOGY
|
| リソース情報 |
| 遺伝子材料 |
Mouse E-cadherin full length cDNA (RDB01184) |
