論文 - 詳細
| RRC ID | 35698 |
|---|---|
| 著者 | Koyama-Nasu R, Haruta R, Nasu-Nishimura Y, Taniue K, Katou Y, Shirahige K, Todo T, Ino Y, Mukasa A, Saito N, Matsui M, Takahashi R, Hoshino-Okubo A, Sugano H, Manabe E, Funato K, Akiyama T. |
| タイトル | The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells. |
| ジャーナル | Oncogene |
| Abstract |
Increasing evidence suggests that brain tumors arise from the transformation of neural stem/precursor/progenitor cells. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma. Here we show that anaplastic lymphoma kinase (ALK) and its ligand pleiotrophin are required for the self-renewal and tumorigenicity of glioblastoma stem cells (GSCs). Furthermore, we demonstrate that pleiotrophin is transactivated directly by SOX2, a transcription factor essential for the maintenance of both neural stem cells and GSCs. We speculate that the pleiotrophin-ALK axis may be a promising target for the therapy of glioblastoma. |
| 巻・号 | 33(17) |
| ページ | 2236-44 |
| 公開日 | 2014-4-24 |
| DOI | 10.1038/onc.2013.168 |
| PII | onc2013168 |
| PMID | 23686309 |
| MeSH | Anaplastic Lymphoma Kinase Animals Brain Neoplasms / genetics Brain Neoplasms / metabolism* Brain Neoplasms / pathology Carcinogenesis / metabolism* Carrier Proteins / genetics* Carrier Proteins / metabolism Cell Proliferation Cytokines / genetics* Cytokines / metabolism Gene Expression Regulation, Neoplastic Glioblastoma / genetics Glioblastoma / metabolism* Glioblastoma / pathology HEK293 Cells Humans Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Neoplastic Stem Cells / metabolism* Neoplastic Stem Cells / pathology Neoplastic Stem Cells / physiology Receptor Protein-Tyrosine Kinases / metabolism* SOXB1 Transcription Factors / metabolism Transcriptional Activation Tumor Cells, Cultured |
| IF | 7.971 |
| 引用数 | 24 |
| WOS 分野 | ONCOLOGY GENETICS & HEREDITY BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 遺伝子材料 | CS-RfA-CG (RDB04390) pCAG-HIVgp (RDB04394) pCMV-VSV-G-RSV-Rev (RDB04393). |