論文 - 詳細
| RRC ID | 48092 |
|---|---|
| 著者 | Nawa H, Kotani H, Nakanishi S. |
| タイトル | Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing. |
| ジャーナル | Nature |
| Abstract |
A novel mammalian neuropeptide, the tachykinin substance K, is specified by a discrete genomic segment. Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene. Relative amounts of the mRNAs vary in different tissues, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner. |
| 巻・号 | 312(5996) |
| ページ | 729-34 |
| 公開日 | 1984-12-20 |
| DOI | 10.1038/312729a0 |
| PMID | 6083453 |
| MeSH | Amino Acid Sequence Animals Base Sequence Cattle Cloning, Molecular Gene Expression Regulation Genes Nerve Tissue Proteins / genetics* Nervous System Physiological Phenomena Peptides / genetics* Protein Precursors / genetics* RNA Splicing* RNA, Messenger / genetics Substance P / genetics* Tachykinins Tissue Distribution |
| IF | 42.779 |
| 引用数 | 521 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 遺伝子材料 | lambda bSP 11 (RDB13171) lambda bSP 15 (RDB13172) lambda bSP 20 (RDB13173) lambda bSP 21 (RDB13174). |