論文 - 詳細
| RRC ID | 48102 |
|---|---|
| 著者 | Takumi T, Ohkubo H, Nakanishi S. |
| タイトル | Cloning of a membrane protein that induces a slow voltage-gated potassium current. |
| ジャーナル | Science |
| Abstract |
A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization. |
| 巻・号 | 242(4881) |
| ページ | 1042-5 |
| 公開日 | 1988-11-18 |
| DOI | 10.1126/science.3194754 |
| PMID | 3194754 |
| MeSH | Amino Acid Sequence Animals Base Sequence Blotting, Northern Cloning, Molecular DNA / genetics Electric Conductivity Membrane Potentials Membrane Proteins / genetics* Molecular Sequence Data Molecular Weight Potassium Channels / physiology* Rats Xenopus laevis |
| IF | 41.846 |
| 引用数 | 458 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 遺伝子材料 | pKI 27 (RDB13187) |