RRC ID 50601
著者 Hikida T, Kimura K, Wada N, Funabiki K, Nakanishi S.
タイトル Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior.
ジャーナル Neuron
Abstract In the basal ganglia, convergent input and dopaminergic modulation of the direct striatonigral and the indirect striatopallidal pathways are critical in rewarding and aversive learning and drug addiction. To explore how the basal ganglia information is processed and integrated through these two pathways, we developed a reversible neurotransmission blocking technique, in which transmission of each pathway was selectively blocked by specific expression of transmission-blocking tetanus toxin in a doxycycline-dependent manner. The results indicated that the coordinated modulation of these two pathways was necessary for dopamine-mediated acute psychostimulant actions. This modulation, however, shifted to the predominant roles of the direct pathway in reward learning and cocaine sensitization and the indirect pathway in aversive behavior. These two pathways thus have distinct roles: the direct pathway critical for distinguishing associative rewarding stimuli from nonassociative ones and the indirect pathway for rapid memory formation to avoid aversive stimuli.
巻・号 66(6)
ページ 896-907
公開日 2010-6-24
DOI 10.1016/j.neuron.2010.05.011
PII S0896-6273(10)00379-X
PMID 20620875
MeSH Action Potentials / drug effects Adaptation, Physiological / drug effects Adaptation, Physiological / genetics Analysis of Variance Animals Avoidance Learning / drug effects Avoidance Learning / physiology* Behavior, Animal Central Nervous System Stimulants / pharmacology Cholera Toxin / metabolism Cocaine / pharmacology Conditioning, Operant / drug effects Corpus Striatum / cytology* Corpus Striatum / drug effects Corpus Striatum / physiology* Dependovirus / physiology Dopamine Uptake Inhibitors / pharmacology Doxycycline / administration & dosage Doxycycline / pharmacology Enzyme-Linked Immunosorbent Assay / methods Gene Expression Regulation / drug effects Methamphetamine / pharmacology Mice Mice, Transgenic Neural Pathways / physiology Neurons / drug effects Neurons / physiology Neurotoxins Proto-Oncogene Proteins c-fos / genetics Proto-Oncogene Proteins c-fos / metabolism RNA, Messenger / metabolism Recombinant Fusion Proteins / genetics Reward* Substantia Nigra / cytology Synaptic Transmission / physiology* Tetanus Toxin Transfection / methods Vesicle-Associated Membrane Protein 2 / genetics Vesicle-Associated Membrane Protein 2 / metabolism
IF 14.415
引用数 325
リソース情報
遺伝子材料 pAAV-Enk-FtTA (RDB13211) pAAV-SP-FtTA (RDB13212).