| RRC ID |
6182
|
| 著者 |
Lee JH, Shin SY, Kim S, Choo J, Lee YH.
|
| タイトル |
Suppression of PTEN expression during aggregation with retinoic acid in P19 mouse embryonal carcinoma cells.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Apoptosis is thought to be involved in the maintenance of cellular homeostasis, as well as various pathological processes. However, little information is available about the regulation of apoptosis during the aggregation stage of P19 embryonal carcinoma (EC) cells. Here we report that aggregation-induced apoptosis is markedly attenuated by treatment with retinoic acid (RA). PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression was down-regulated during the aggregation phase of P19 EC cells in the presence, but not in the absence, of RA. Suppression of PTEN expression during the aggregation was accompanied by increased phosphorylation of serine/threonine kinase Akt and glycogen synthase kinase-3beta (GSK-3beta). Our results suggest that RA attenuates the induction of apoptosis during the aggregation phase of P19 EC cells, probably by suppressing PTEN expression.
|
| 巻・号 |
347(3)
|
| ページ |
715-22
|
| 公開日 |
2006-9-1
|
| DOI |
10.1016/j.bbrc.2006.06.161
|
| PII |
S0006-291X(06)01464-1
|
| PMID |
16842746
|
| MeSH |
Animals
Apoptosis / drug effects
Carcinoma, Embryonal / genetics
Carcinoma, Embryonal / metabolism*
Carcinoma, Embryonal / pathology
Cell Differentiation
Cell Shape / drug effects
Down-Regulation / drug effects
Enzyme Activation / drug effects
Gene Expression Regulation, Neoplastic
Mice
PTEN Phosphohydrolase / genetics
PTEN Phosphohydrolase / metabolism*
Poly(ADP-ribose) Polymerases / metabolism
Proto-Oncogene Proteins c-akt / metabolism
Transcription, Genetic / genetics
Tretinoin / pharmacology*
|
| IF |
2.985
|
| 引用数 |
15
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 遺伝子材料 |
AxCAhPTEN1 (RDB02012)
AxCALacZ (RDB01745). |
