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Reference Info.
Pubmed ID 21208906  
RRC ID 17609 
Author Bachleitner-Hofmann T, Sun MY, Chen CT, Liska D, Zeng Z, Viale A, Olshen AB, Mittlboeck M, Christensen JG, Rosen N, Solit DB, Weiser MR. 
Title Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition. 
Journal Clin. Cancer Res. 
Published 2011-1-7 
Volume 17(1) 
Pages 122-33 
DOI 10.1158/1078-0432.CCR-10-0253   
PII 17/1/122 
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
HSP90 Heat-Shock Proteins / antagonists & inhibitors*
Heterocyclic Compounds, 4 or More Rings / pharmacology*
Indoles / pharmacology
Mice, Inbred BALB C
Mice, Nude
Protein Kinase Inhibitors / pharmacology
Proto-Oncogene Proteins c-met / antagonists & inhibitors*
Proto-Oncogene Proteins c-met / metabolism
Structure-Activity Relationship
Sulfones / pharmacology
Resource Info.
Species Human and Animal Cells 
Resource name
MKN45 (RCB1001

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