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Reference Info.
Pubmed ID 23319657  
RRC ID 19666 
Author Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung UI, Kawaguchi H. 
Title Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development. 
Journal Proc. Natl. Acad. Sci. U.S.A. 
Published 2013-1-29 
Volume 110(5) 
Pages 1875-80 
DOI 10.1073/pnas.1207458110   
PII 1207458110 
Basic Helix-Loop-Helix Transcription Factors / genetics
Basic Helix-Loop-Helix Transcription Factors / metabolism
Calcium-Binding Proteins / genetics
Calcium-Binding Proteins / metabolism
Cartilage / drug effects
Cartilage / metabolism
Cartilage / pathology
Cell Line
Cell Line, Tumor
Chondrocytes / drug effects
Chondrocytes / metabolism*
Collagen Type II / genetics
Collagen Type II / metabolism
Dipeptides / pharmacology
Fluorescent Antibody Technique
HeLa Cells
Homeodomain Proteins / genetics
Homeodomain Proteins / metabolism
Immunoglobulin J Recombination Signal Sequence-Binding Protein / genetics
Immunoglobulin J Recombination Signal Sequence-Binding Protein / metabolism
Intercellular Signaling Peptides and Proteins / genetics
Intercellular Signaling Peptides and Proteins / metabolism
Knee Joint / drug effects
Knee Joint / metabolism
Knee Joint / pathology
Membrane Proteins / genetics
Membrane Proteins / metabolism
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Osteoarthritis / genetics
Osteoarthritis / metabolism*
Osteoarthritis / prevention & control
Receptor, Notch1 / antagonists & inhibitors
Receptor, Notch1 / genetics
Receptor, Notch1 / metabolism*
Receptor, Notch2 / antagonists & inhibitors
Receptor, Notch2 / genetics
Receptor, Notch2 / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
SOX9 Transcription Factor / genetics
SOX9 Transcription Factor / metabolism
Signal Transduction*
Resource Info.
Species Mice 
Resource name

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