RRC ID 2069
著者 Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.
タイトル Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.
ジャーナル Hepatol Res
Abstract Anemia of chronic disease (ACD) is commonly observed in chronic inflammation, although its pathogenesis is poorly understood. Hepcidin is thought to be a key regulator in iron metabolism and has been implicated in ACD. Although the induction of hepcidin by an inflammatory cytokine interleukin-6 (IL-6) seems to have been confirmed, it is still controversial whether interleukin-1beta (IL-1beta), also known as an inflammatory cytokine, regulates hepcidin expression. We demonstrated that hepcidin mRNA was upregulated by IL-1beta in human hepatoma-derived HuH-7 cells, particularly at low concentrations of IL-1beta, while high concentrations of IL-6 were needed for the upregulation of hepcidin mRNA. Therefore, IL-1beta might be more important for the upregulation of hepcidin in physiological conditions than IL-6. Although IL-1beta induces IL-6 production in hepatocytes, our data indicate that the effect of IL-1beta on hepcidin expression is independent from that of IL-6. In conclusion, IL-1beta might have an important role in ACD.
巻・号 33(3)
ページ 198-205
公開日 2005-11-1
DOI 10.1016/j.hepres.2005.08.005
PII S1386-6346(05)00253-6
PMID 16198622
IF 3.165
引用数 32
WOS 分野 GASTROENTEROLOGY & HEPATOLOGY
リソース情報
ヒト・動物細胞 HuH-7(RCB1366) Hep G2(RCB0459) CACO-2(RCB0988) U-937 DE-4(RCB0435) THP-1(RCB1189)