RRC ID 2098
Author Venken KJ, Bellen HJ.
Title Transgenesis upgrades for Drosophila melanogaster.
Journal Development
Abstract Drosophila melanogaster is a highly attractive model system for the study of numerous biological questions pertaining to development, genetics, cell biology, neuroscience and disease. Until recently, our ability to manipulate flies genetically relied heavily on the transposon-mediated integration of DNA into fly embryos. However, in recent years significant improvements have been made to the transgenic techniques available in this organism, particularly with respect to integrating DNA at specific sites in the genome. These new approaches will greatly facilitate the structure-function analyses of Drosophila genes, will enhance the ease and speed with which flies can be manipulated, and should advance our understanding of biological processes during normal development and disease.
Volume 134(20)
Pages 3571-84
Published 2007-10
DOI 10.1242/dev.005686
PII 134/20/3571
PMID 17905790
MeSH Animals Animals, Genetically Modified DNA Repair DNA Transposable Elements / genetics Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics* Drosophila melanogaster / physiology Gene Transfer Techniques* Genetic Markers Genome Recombination, Genetic Transgenes*
IF 5.763
Times Cited 84