RRC ID 30073
Author Demple B, Halbrook J, Linn S.
Title Escherichia coli xth mutants are hypersensitive to hydrogen peroxide.
Journal J. Bacteriol.
Abstract Escherichia coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-induced lethality and the in vivo role of exonuclease III.
Volume 153(2)
Pages 1079-82
Published 1983-2
PMID 6337115
PMC PMC221738
MeSH Catalase / metabolism Escherichia coli / drug effects* Escherichia coli / enzymology Escherichia coli / genetics Exodeoxyribonucleases / physiology* Hydrogen Peroxide / pharmacology* Mutation Phenotype
IF 3.219
Times Cited 177
Prokaryotes E. coli ME7765