| RRC ID |
33930
|
| 著者 |
Pham TL, Shimizu K, Dao TS, Hong-Do LC, Utsumi M.
|
| タイトル |
Microcystin uptake and biochemical responses in the freshwater clam Corbicula leana P. exposed to toxic and non-toxic Microcystis aeruginosa: Evidence of tolerance to cyanotoxins.
|
| ジャーナル |
Toxicol Rep
|
| Abstract |
We investigated the accumulation and adverse effects of toxic and non-toxic Microcystis in the edible clam Corbicula leana. Treated clams were exposed to toxic Microcystis at 100 μg of MC (microcystin)-LReq L-1 for 10 days. The experimental organism was then placed in toxin-free water and fed on non-toxic Microcystis for the following 10 days for depuration. Filtering rates (FRs) by C. leana of toxic and non-toxic Microcystis and of the green alga Chlorella vulgaris as a control were estimated. Adverse effects were evaluated though the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione S-transferase (GST). Clam accumulated MCs (up to 12.7 ± 2.5 μg g-1 dry weight (DW) of free MC and 4.2 ± 0.6 μg g-1 DW of covalently bound MC). Our results suggest that although both toxic and non-toxic cyanobacteria caused adverse effects by inducing the detoxification and antioxidant defense system, the clam was quite resistant to cyanotoxins. The estimated MC concentration in C. leana was far beyond the World Health Organization's (WHO) provisional tolerable daily intake (0.04 μg kg-1 day-1), suggesting that consuming clams harvested during cyanobacterial blooms carries a high health risk.
|
| 巻・号 |
2
|
| ページ |
88-98
|
| 公開日 |
2015-1-1
|
| DOI |
10.1016/j.toxrep.2015.01.012
|
| PII |
S2214-7500(15)00014-1
|
| PMID |
28962341
|
| PMC |
PMC5598480
|
| 引用数 |
14
|
| リソース情報 |
| 藻類 |
NIES-101
NIES-1086
NIES-2170 |
