RRC ID 345
著者 Baines JF, Das A, Mousset S, Stephan W.
タイトル The role of natural selection in genetic differentiation of worldwide populations of Drosophila ananassae.
ジャーナル Genetics
Abstract The main evolutionary forces leading to genetic differentiation between populations are generally considered to be natural selection, random genetic drift, and limited migration. However, little empirical evidence exists to help explain the extent, mechanism, and relative role of these forces. In this study, we make use of the differential migration behavior of genes located in regions of low and high recombination to infer the role and demographic distribution of natural selection in Drosophila ananassae. Sequence data were obtained from 13 populations, representing almost the entire range of cosmopolitan D. ananassae. The pattern of variation at a 5.1-kb fragment of the furrowed gene, located in a region of very low recombination, appears strikingly different from that of 10 noncoding DNA fragments (introns) in regions of normal to high recombination. Most interestingly, two main haplotypes are present at furrowed, one being fixed in northern populations and the other being fixed or in high frequency in more southern populations. A cline in the frequency of one of these haplotypes occurs in parallel latitudinal transects. Taken together, significant clinal variation and a test against alternative models of natural selection provide evidence of two independent selective sweeps restricted to specific regions of the species range.
巻・号 168(4)
ページ 1987-98
公開日 2004-12-1
DOI 10.1534/genetics.104.027482
PII 168/4/1987
PMID 15611169
PMC PMC1448739
MeSH Animals Base Sequence Drosophila / genetics* Genetic Variation* Genetics, Population Haplotypes Molecular Sequence Data Polymorphism, Genetic Selection, Genetic*
IF 4.015
引用数 25
WOS 分野 GENETICS & HEREDITY
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