RRC ID 36965
Author Kawauchi K, Ogasawara T, Aiba M, Fujibayashi M, Sanaka T, Sakura H, Shibuya M.
Title Establishment and characterization of a novel VEGF-producing HHV-8-unrelated PEL-like lymphoma cell line, OGU1.
Journal Eur. J. Haematol.
Abstract Primary effusion lymphoma (PEL) is a rare B-cell lymphoma subtype that is characterized by lymphomatous effusion without the presence of masses, and it typically occurs in human immunodeficiency virus (HIV)-infected individuals. Lymphoma cells are universally positive for human herpesvirus 8 (HHV-8). Recently, a cavity-based effusion lymphoma that is similar to PEL without HHV-8 infection, called HHV-8-unrelated PEL-like lymphoma, has been reported in non-HIV-infected individuals. However, the pathophysiology of this lymphoma is largely undefined. We established a novel B-cell line OGU1 derived from a patient with HHV-8-unrelated PEL-like lymphoma. Notably, OGU1 cells produced vascular endothelial growth factor (VEGF) and expressed VEGF receptor 1, whose inhibitors retarded cell growth. Because VEGF acts as a vascular permeability and growth factor, it could play a role, at least in part, in the pathogenesis of this unique lymphoma. Thus, the OGU1 cell line is useful for the investigation of HHV-8-unrelated PEL-like lymphoma.
Volume 96(2)
Pages 144-51
Published 2016-2
DOI 10.1111/ejh.12559
PMID 25846106
MeSH Aged B-Lymphocytes / metabolism B-Lymphocytes / pathology* Capillary Permeability Cell Line, Tumor Founder Effect* Gene Expression Herpesviridae Infections / genetics* Herpesviridae Infections / metabolism Herpesviridae Infections / pathology Herpesvirus 8, Human / pathogenicity Herpesvirus 8, Human / physiology Humans Lymphoma, Primary Effusion / genetics* Lymphoma, Primary Effusion / metabolism Lymphoma, Primary Effusion / pathology Male Vascular Endothelial Growth Factor A / genetics Vascular Endothelial Growth Factor A / metabolism Vascular Endothelial Growth Factor Receptor-1 / genetics Vascular Endothelial Growth Factor Receptor-1 / metabolism
IF 2.217
Times Cited 0
Human and Animal Cells OGU1(RCB2351)