論文 - 詳細
| RRC ID | 39336 |
|---|---|
| 著者 | Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M. |
| タイトル | Antiproliferative activity of flavonoids on several cancer cell lines. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Twenty-seven Citrus flavonoids were examined for their antiproliferative activities against several tumor and normal human cell lines. As a result, 7 flavonoids were judged to be active against the tumor cell lines, while they had weak antiproliferative activity against the normal human cell lines. The rank order of potency was luteolin, natsudaidain, quercetin, tangeretin, eriodictyol, nobiletin, and 3,3',4',5,6,7,8-heptamethoxyflavone. The structure-activity relationship established from comparison among these flavones and flavanones showed that the ortho-catechol moiety in ring B and a C2-C3 double bond were important for the antiproliferative activity. As to polymethoxylated flavones, C-3 hydroxyl and C-8 methoxyl groups were essential for high activity. |
| 巻・号 | 63(5) |
| ページ | 896-9 |
| 公開日 | 1999-5-1 |
| DOI | 10.1271/bbb.63.896 |
| PMID | 10380632 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / pharmacology* Cell Division / drug effects* Cell Line Drug Screening Assays, Antitumor Flavonoids / chemistry Flavonoids / pharmacology* Humans Structure-Activity Relationship Tumor Cells, Cultured |
| IF | 1.516 |
| 引用数 | 246 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) B16 melanoma 4A5(RCB0557) CCRF-HSB-2(RCB0016) TGBC11TKB(RCB1148) |