| RRC ID |
41327
|
| Author |
Takagi S, Fujikawa K, Imai T, Fukuhara N, Fukudome K, Minegishi M, Tsuchiya S, Konno T, Hinuma Y, Yoshie O.
|
| Title |
Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily.
|
| Journal |
Int J Cancer
|
| Abstract |
Five monoclonal antibodies detected a surface antigen expressed exclusively on T-cell acute lymphoblastic leukemia (T-ALL) in a panel of 45 human hematopoietic cell lines, including T-cell lines derived from adult T-cell leukemia and those established by immortalization with human T-cell leukemia virus type 1 or Herpesvirus saimiri. Peripheral blood mononuclear cells, including fresh and activated T cells, were also completely devoid of this antigen. We designated this antigen as TALLA-1 (from T-ALL-associated antigen 1). By expression cloning, a cDNA clone encoding TALLA-1 was isolated from T-ALL cell line Molt-4. TALLA-1 was found to be a member of the transmembrane 4 superfamily (TM4SF). The cDNA was also essentially identical to A15, which was isolated from another T-ALL cell line, HPB-ALL, by differential hybridization with normal peripheral blood lymphocytes, and to CCG-B7, which was isolated from a brain cDNA library using CCG repeat as a probe. The gene product was now characterized in detail at the protein level. Northern blot analysis showed that the gene was expressed most strongly in brain, skeletal muscle and spleen. In a panel of 52 non-hematopoietic human cell lines, the majority of neuroblastoma cell lines were found to be positive for TALLA-1. Like ME491, CO-029 and L6, TALLA-1 may be another TM4SF member behaving as a potential tumor-associated antigen.
|
| Volume |
61(5)
|
| Pages |
706-15
|
| Published |
1995-5-29
|
| DOI |
10.1002/ijc.2910610519
|
| PMID |
7768645
|
| MeSH |
Amino Acid Sequence
Antibodies, Monoclonal
Antigens, Neoplasm / immunology*
Antigens, Surface / analysis
Base Sequence
Blotting, Northern
Brain / metabolism
Humans
Leukemia-Lymphoma, Adult T-Cell / immunology*
Molecular Sequence Data
Muscle, Skeletal / metabolism
Neuroblastoma / immunology*
Spleen / metabolism
Tumor Cells, Cultured
|
| IF |
5.145
|
| Times Cited |
51
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
|
