| RRC ID |
42764
|
| 著者 |
Yamagishi N, Tokunaga S, Ishihara K, Saito Y, Hatayama T.
|
| タイトル |
The phenylic hydroxyl group is essential for the induction of stress response by sodium salicylate.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
We have shown that sodium salicylate (SA) activates the heat shock promoter and induces the expression of heat shock proteins (Hsps) with a concomitant increase in the thermotolerance of cells. To identify the functional groups of SA necessary for the induction of Hsps, we evaluated the effect of various derivatives of SA using a mammalian cell line containing a reporter gene downstream of an hsp105 promoter. Among the derivatives, the compounds in which the carboxyl group of SA was substituted activated the hsp105 promoter at 37 degrees C as SA did, but the compounds in which the hydroxyl group was substituted did not. Thus, the phenylic hydroxyl group but not the carboxyl group of SA seemed to be necessary for a stress-induced response. In addition, the orientation of two functional groups on the benzene ring of SA derivatives was also important for the induction of a response. Among these compounds, salicylalcohol which strongly induced the expression of Hsps suppressed the protein aggregation and apoptosis caused by an expanded polyglutamine tract in a cellular model of polyglutamine disease. These findings may aid in the development of novel effective Hsp-inducers.
|
| 巻・号 |
350(1)
|
| ページ |
131-7
|
| 公開日 |
2006-11-10
|
| DOI |
10.1016/j.bbrc.2006.09.008
|
| PII |
S0006-291X(06)02029-8
|
| PMID |
16996033
|
| MeSH |
Animals
Cell Line
Cell Survival / drug effects
Chlorocebus aethiops
Heat-Shock Proteins / metabolism
Heat-Shock Response / drug effects*
Humans
Hydroxylation
Mice
Phenol / chemistry*
Sodium Salicylate / chemistry*
Sodium Salicylate / pharmacology*
Sodium Salicylate / toxicity
|
| IF |
2.985
|
| 引用数 |
3
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
