RRC ID 43562
Author Houzet L, Jeang KT.
Title Genome-wide screening using RNA interference to study host factors in viral replication and pathogenesis.
Journal Exp Biol Med (Maywood)
Abstract With the recent development of short interfering RNA and short hairpin RNA expression libraries, RNA interference (RNAi) technology has been extensively employed to identify genes involved in diverse cellular processes, such as signal transduction, cell cycle, cancer biology and host-pathogen interactions. In the field of viral infection, this approach has already identified hundreds of new genes not previously known to be important for various virus lifecycles. In this brief review, we focus on recent studies performed using genome-wide RNAi-based screens in mammalian cells for the identification of essential host factors for viral infection and pathogenesis.
Volume 236(8)
Pages 962-7
Published 2011-8-1
DOI 10.1258/ebm.2010.010272
PII ebm.2010.010272
PMID 21727185
PMC PMC3415036
MeSH Animals Genome* Host-Pathogen Interactions / genetics Humans RNA Interference* RNA, Small Interfering / genetics Virus Replication / genetics* Viruses / genetics Viruses / pathogenicity*
IF 3.139
Times Cited 21
Human and Animal Cells