論文 - 詳細
| RRC ID | 43599 |
|---|---|
| 著者 | Sueyoshi T, Jono H, Shinriki S, Ota K, Ota T, Tasaki M, Atsuyama E, Yakushiji T, Ueda M, Obayashi K, Mizuta H, Ando Y. |
| タイトル | Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma. |
| ジャーナル | Cancer Lett |
| Abstract |
Midkine (MK) plays important roles in tumorigenesis, however, the biological function of MK and whether MK can be a therapeutic target in osteosarcoma are unclear. Here, we found that osteosarcoma tissues showed high MK expression. MK knockdown by small interfering RNA significantly induced apoptosis in osteosarcoma cells, whereas recombinant MK increased cell proliferation. Inhibition of MK signaling by anti-MK monoclonal antibody (anti-MK mAb) suppressed growth of osteosarcoma cells both in vitro and in vivo. Moreover, inhibition of MK function significantly suppressed lung metastasis in xenograft transplantation model. Targeting MK by anti-MK mAb may have value in the treatment of osteosarcoma. |
| 巻・号 | 316(1) |
| ページ | 23-30 |
| 公開日 | 2012-3-1 |
| DOI | 10.1016/j.canlet.2011.10.013 |
| PII | S0304-3835(11)00630-6 |
| PMID | 22099874 |
| MeSH | Adolescent Adult Aged Antibodies, Monoclonal / therapeutic use Apoptosis / genetics Bone Neoplasms / genetics Bone Neoplasms / metabolism Bone Neoplasms / pathology Bone Neoplasms / therapy* Cell Cycle Checkpoints / genetics Cell Growth Processes Cell Transformation, Neoplastic / genetics Cell Transformation, Neoplastic / metabolism Child Cytokines / antagonists & inhibitors* Cytokines / deficiency* Cytokines / genetics Cytokines / metabolism Female Gene Knockdown Techniques / methods Humans Lung Neoplasms / genetics Lung Neoplasms / metabolism Lung Neoplasms / prevention & control* Lung Neoplasms / secondary* Male Middle Aged Midkine Molecular Targeted Therapy Osteosarcoma / genetics Osteosarcoma / metabolism Osteosarcoma / secondary Osteosarcoma / therapy* RNA, Small Interfering / administration & dosage RNA, Small Interfering / genetics Sarcoma / genetics Sarcoma / metabolism Sarcoma / pathology Sarcoma / therapy* Tumor Cells, Cultured Young Adult |
| IF | 7.36 |
| 引用数 | 22 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |