Reference - Detail
|Author||Lee YS, Cha BY, Choi SS, Harada Y, Choi BK, Yonezawa T, Teruya T, Nagai K, Woo JT.|
|Title||Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice.|
This study examined the effects of fargesin, a neolignan isolated from Magnolia plants, on obesity and insulin resistance and the possible mechanisms involved in these effects in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese mice. Fargesin promoted the glucose uptake in 3T3-L1 adipocytes. In HFD-induced obese mice, fargesin decreased the body weight gain, white adipose tissue (WAT), and plasma triglyceride, non-esterified fatty acid and glucose levels, and improved the glucose tolerance. Fargesin increased glucose transporter 4 (GLUT4) protein expression and phosphorylation of Akt, AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC) in both 3T3-L1 adipocytes and WAT of HFD-induced obese mice. Fargesin also decreased the mRNA expression levels of fatty acid oxidation-related genes, such as peroxisome proliferator-activated receptor α (PPARα), carnitine palmitoyltransferase-1 (CPT-1), uncoupling protein-2 (UCP-2) and leptin in WAT. Taken together, the present findings suggest that fargesin improves dyslipidemia and hyperglycemia by activating Akt and AMPK in WAT.
|MeSH||3T3-L1 Cells Acetyl-CoA Carboxylase / metabolism Adenylate Kinase / metabolism Adipocytes / drug effects Adipocytes / metabolism Animals Benzodioxoles / pharmacology* Benzodioxoles / therapeutic use Blood Glucose Diet, High-Fat / adverse effects* Gene Expression / drug effects Glucose / metabolism* Glucose Transporter Type 4 / metabolism Hypoglycemic Agents / pharmacology* Hypoglycemic Agents / therapeutic use Hypolipidemic Agents / pharmacology* Hypolipidemic Agents / therapeutic use Lignans / pharmacology* Lignans / therapeutic use Lipid Metabolism / drug effects* Lipids / blood Male Mice Mice, Inbred C57BL Mice, Obese Obesity / drug therapy Obesity / etiology Obesity / metabolism* Organ Size / drug effects Phosphorylation Protein Processing, Post-Translational Proto-Oncogene Proteins c-akt / metabolism Weight Gain / drug effects|
|WOS Category||ENDOCRINOLOGY & METABOLISM BIOCHEMISTRY & MOLECULAR BIOLOGY|
|Human and Animal Cells|