論文 - 詳細
| RRC ID | 43889 |
|---|---|
| 著者 | Lee YS, Cha BY, Choi SS, Harada Y, Choi BK, Yonezawa T, Teruya T, Nagai K, Woo JT. |
| タイトル | Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice. |
| ジャーナル | Biofactors |
| Abstract |
This study examined the effects of fargesin, a neolignan isolated from Magnolia plants, on obesity and insulin resistance and the possible mechanisms involved in these effects in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese mice. Fargesin promoted the glucose uptake in 3T3-L1 adipocytes. In HFD-induced obese mice, fargesin decreased the body weight gain, white adipose tissue (WAT), and plasma triglyceride, non-esterified fatty acid and glucose levels, and improved the glucose tolerance. Fargesin increased glucose transporter 4 (GLUT4) protein expression and phosphorylation of Akt, AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC) in both 3T3-L1 adipocytes and WAT of HFD-induced obese mice. Fargesin also decreased the mRNA expression levels of fatty acid oxidation-related genes, such as peroxisome proliferator-activated receptor α (PPARα), carnitine palmitoyltransferase-1 (CPT-1), uncoupling protein-2 (UCP-2) and leptin in WAT. Taken together, the present findings suggest that fargesin improves dyslipidemia and hyperglycemia by activating Akt and AMPK in WAT. |
| 巻・号 | 38(4) |
| ページ | 300-8 |
| 公開日 | 2012-1-1 |
| DOI | 10.1002/biof.1022 |
| PMID | 22674784 |
| MeSH | 3T3-L1 Cells Acetyl-CoA Carboxylase / metabolism Adenylate Kinase / metabolism Adipocytes / drug effects Adipocytes / metabolism Animals Benzodioxoles / pharmacology* Benzodioxoles / therapeutic use Blood Glucose Diet, High-Fat / adverse effects* Gene Expression / drug effects Glucose / metabolism* Glucose Transporter Type 4 / metabolism Hypoglycemic Agents / pharmacology* Hypoglycemic Agents / therapeutic use Hypolipidemic Agents / pharmacology* Hypolipidemic Agents / therapeutic use Lignans / pharmacology* Lignans / therapeutic use Lipid Metabolism / drug effects* Lipids / blood Male Mice Mice, Inbred C57BL Mice, Obese Obesity / drug therapy Obesity / etiology Obesity / metabolism* Organ Size / drug effects Phosphorylation Protein Processing, Post-Translational Proto-Oncogene Proteins c-akt / metabolism Weight Gain / drug effects |
| IF | 4.734 |
| 引用数 | 17 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |