RRC ID 43889
Author Lee YS, Cha BY, Choi SS, Harada Y, Choi BK, Yonezawa T, Teruya T, Nagai K, Woo JT.
Title Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice.
Journal Biofactors
Abstract This study examined the effects of fargesin, a neolignan isolated from Magnolia plants, on obesity and insulin resistance and the possible mechanisms involved in these effects in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese mice. Fargesin promoted the glucose uptake in 3T3-L1 adipocytes. In HFD-induced obese mice, fargesin decreased the body weight gain, white adipose tissue (WAT), and plasma triglyceride, non-esterified fatty acid and glucose levels, and improved the glucose tolerance. Fargesin increased glucose transporter 4 (GLUT4) protein expression and phosphorylation of Akt, AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC) in both 3T3-L1 adipocytes and WAT of HFD-induced obese mice. Fargesin also decreased the mRNA expression levels of fatty acid oxidation-related genes, such as peroxisome proliferator-activated receptor α (PPARα), carnitine palmitoyltransferase-1 (CPT-1), uncoupling protein-2 (UCP-2) and leptin in WAT. Taken together, the present findings suggest that fargesin improves dyslipidemia and hyperglycemia by activating Akt and AMPK in WAT.
Volume 38(4)
Pages 300-8
Published 2012-7
DOI 10.1002/biof.1022
PMID 22674784
MeSH 3T3-L1 Cells Acetyl-CoA Carboxylase / metabolism Adenylate Kinase / metabolism Adipocytes / drug effects Adipocytes / metabolism Animals Benzodioxoles / pharmacology* Benzodioxoles / therapeutic use Blood Glucose Diet, High-Fat / adverse effects* Gene Expression / drug effects Glucose / metabolism* Glucose Transporter Type 4 / metabolism Hypoglycemic Agents / pharmacology* Hypoglycemic Agents / therapeutic use Hypolipidemic Agents / pharmacology* Hypolipidemic Agents / therapeutic use Lignans / pharmacology* Lignans / therapeutic use Lipid Metabolism / drug effects* Lipids / blood Male Mice Mice, Inbred C57BL Mice, Obese Obesity / drug therapy Obesity / etiology Obesity / metabolism* Organ Size / drug effects Phosphorylation Protein Processing, Post-Translational Proto-Oncogene Proteins c-akt / metabolism Weight Gain / drug effects
IF 3.598
Times Cited 9
Human and Animal Cells