RRC ID 43970
著者 Doi K, Fujimoto T, Okamura T, Ogawa M, Tanaka Y, Mototani Y, Goto M, Ota T, Matsuzaki H, Kuroki M, Tsunoda T, Sasazuki T, Shirasawa S.
タイトル ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response.
ジャーナル Biochem Biophys Res Commun
Abstract ZFAT, originally identified as a candidate susceptibility gene for autoimmune thyroid disease, has been reported to be involved in apoptosis, development and primitive hematopoiesis. Zfat is highly expressed in T- and B-cells in the lymphoid tissues, however, its physiological function in the immune system remains totally unknown. Here, we generated the T cell-specific Zfat-deficient mice and demonstrated that Zfat-deficiency leads to a remarkable reduction in the number of the peripheral T cells. Intriguingly, a reduced expression of IL-7Rα and the impaired responsiveness to IL-7 for the survival were observed in the Zfat-deficient T cells. Furthermore, a severe defect in proliferation and increased apoptosis in the Zfat-deficient T cells following T cell receptor (TCR) stimulation was observed with a reduced IL-2Rα expression as well as a reduced IL-2 production. Thus, our findings reveal that Zfat is a critical regulator in peripheral T cell homeostasis and its TCR-mediated response.
巻・号 425(1)
ページ 107-12
公開日 2012-8-17
DOI 10.1016/j.bbrc.2012.07.065
PII S0006-291X(12)01361-7
PMID 22828507
MeSH Animals Apoptosis / immunology CD4 Lymphocyte Count CD4-Positive T-Lymphocytes / immunology* Cell Proliferation Homeostasis / immunology* Interleukin-7 / pharmacology Mice Mice, Mutant Strains Receptors, Antigen, T-Cell / immunology* Receptors, Interleukin-7 / biosynthesis Transcription Factors / genetics Transcription Factors / physiology*
IF 2.985
引用数 12
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞