| RRC ID |
4476
|
| 著者 |
Kuromori T, Takahashi S, Kondou Y, Shinozaki K, Matsui M.
|
| タイトル |
Phenome analysis in plant species using loss-of-function and gain-of-function mutants.
|
| ジャーナル |
Plant Cell Physiol
|
| Abstract |
Analysis of genetic mutations is one of the most effective ways to investigate gene function. We now have methods that allow for mass production of mutant lines and cells in a variety of model species. Recently, large numbers of mutant lines have been generated by both 'loss-of-function' and 'gain-of-function' techniques. In parallel, phenotypic information covering various mutant resources has been acquired and released in web-based databases. As a result, significant progress in comprehensive phenotype analysis is being made through the use of these tools. Arabidopsis and rice are two major model plant species in which genome sequencing projects have been completed. Arabidopsis is the most widely used experimental plant, with a large number of mutant resources and several examples of systematic phenotype analysis. Rice is a major crop species and is used as a model plant, with an increasing number of mutant resources. Other plant species are also being employed in functional genetics research. In this review, the present status of mutant resources for large-scale studies of gene function in plant research and the current perspective on using loss-of-function and gain-of-function mutants in phenome research will be discussed.
|
| 巻・号 |
50(7)
|
| ページ |
1215-31
|
| 公開日 |
2009-7-1
|
| DOI |
10.1093/pcp/pcp078
|
| PII |
pcp078
|
| PMID |
19502383
|
| PMC |
PMC2709550
|
| MeSH |
Arabidopsis / genetics
DNA, Plant / genetics
Databases, Genetic
Genes, Plant*
Genome, Plant*
Genomics / methods*
Mutagenesis, Insertional
Mutation
Oryza / genetics
Phenotype
Plants, Genetically Modified / genetics
|
| IF |
4.062
|
| 引用数 |
58
|
|
WOS 分野
|
PLANT SCIENCES
CELL BIOLOGY
|
| リソース情報 |
| 情報 |
LegumeBase |
