RRC ID 56791
著者 Takayuki Hoshino, Moto Yoshioka, Akira Wagatsuma, Hiroki Miyazako, Kunihiko Mabuchi
タイトル Fine virtual cathode display for biomolecules control and cell nano surgery
ジャーナル 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)
Abstract Electron beam (EB) induced fine virtual cathode (VC) on a 100-nm-thick SiN membrane has been developed using inverted-EB lithography (I-EBL). Here we present electrokinetic property of the VC for biological materials and instantly control their spatio-temporal responses using the VC. Negatively charged biomolecules (proteins, DNAs) respond to locally injected negative electrons of VC, and change their electrostatic interaction which affects the molecular aggregation/dissociation and adhesion/detachment in water solution. So, we call this technique virtual cathode display for biomolecules. This technique was applied to in-situ molecules patterning for mechanical strain microscopy and pinpoint transmembrane molecules delivery.
公開日 2017-1-1
DOI 10.1109/MEMSYS.2017.7863471
リソース情報
ヒト・動物細胞 C2C12(RCB0987)