RRC ID 56803
著者 Chihiro Okutani, Akira Wagatsuma, Kunihiko Mabuchi and Takayuki Hoshino
タイトル Cell descent caused by boundary curvature of a high topographical structure for a device that changes cell density
ジャーナル Japanese Journal of Applied Physics
Abstract Noninvasive techniques of controlling cell migration on substrates are widely useful for tissue engineering. However, the cell migration controls of previous studies were not enough for collecting cells locally. To solve this problem, in this work, we report the C2C12 mouse myoblast cell migration difference (descend or be repelled) by changing the curvature of the boundary of a topographical structure when the cells move from a flat surface to the boundary. 69% of the cells coming across a round boundary — the curvature radius of which was 50 µm — descended into the hole. In contrast, no cells descended into a groove with a linear boundary. Moreover, we demonstrated the cell spatial density change from the difference at the boundary. This finding will provide a new device that will enable us to manipulate spatial cell density noninvasively for tissue engineering.
巻・号 56
公開日 2017-5-23
DOI 10.7567/JJAP.56.06GM03
引用数 2
リソース情報
ヒト・動物細胞 C2C12(RCB0987)