| RRC ID |
56843
|
| 著者 |
Hsing‐An Lin, Bo Zhu, Yu‐Wei Wu, Jun Sekine, Aiko Nakao, Shyh‐Chyang Luo, Yoshiro Yamashita, Hsiao‐Hua Yu
|
| タイトル |
Dynamic Poly(3,4‐ethylenedioxythiophene)s Integrate Low Impedance with Redox‐Switchable Biofunction
|
| ジャーナル |
Advanced Functional Materials
|
| Abstract |
To generate the electrical communication, biocompatibility, and controlled cell attachment properties required for advanced bioelectronic technologies, a dynamic poly(3,4‐ethylenedioxythiophene) (PEDOT) film is developed based on a biomimetic approach. The dynamic PEDOT integrates low impedance, nonspecific‐binding resistance, and redox‐responsive characteristics while coupling with cells stably and specifically. The combination of these features ensures stable and efficient electrical communication with cells and promises potentially reduced disruption of complexes in physiological environments due to the material's strong resistance to nonspecific interactions; more significantly, the integration of these features in one material enables the spatiotemporal attachment and detachment of cells on demand without damage to cell viability and neurites after 5 d of electrical stimulation and culturing. The dynamic and biomimetic PEDOT material can be an ideal electronic interface with optimized electrochemical and biological characteristics toward biocompatible and controllable electrocoupling with cells at low impedance.
|
| 巻・号 |
28
|
| 公開日 |
2018-1-15
|
| DOI |
10.1002/adfm.201703890
|
| IF |
16.836
|
| 引用数 |
10
|
| リソース情報 |
| ヒト・動物細胞 |
PC-12(RCB0009) |
