RRC ID 60111
著者 Taniguchi A, Sawazaki T, Shimizu Y, Sohma Y, Kanai M.
タイトル Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs.
ジャーナル Medchemcomm
Abstract The photophysical properties of newly identified B,B-fluoro-perfluoroalkyl BODIPYs (2 and 3), which possess a fluoro group and a trifluoromethyl or pentafluoroethyl group at the boron center, were investigated. B,B-Fluoro-perfluoroalkyl BODIPYs 2 and 3 exhibited better photophysical/chemical properties than B,B-difluoro-BODIPY 1, as follows: (1) higher photostability both in methanol solvent and in a live cell environment, (2) higher stability against acid degradation, and (3) improved fluorescence signal-to-noise ratios in a cell system. These favorable properties of B,B-fluoro-perfluoroalkyl BODIPYs are likely due to the highly electron-withdrawing nature of the perfluoroalkyl groups on the boron atom, which reduces the reactivity to 1O2 and strengthens the complexation of the dipyrromethene ligands to the boron atom. Thus, B,B-fluoro perfluoroalkyl BODIPYs may be useful functional molecules for various applications.
巻・号 10(7)
ページ 1121-1125
公開日 2019-7-1
DOI 10.1039/c9md00011a
PII c9md00011a
PMID 31391884
PMC PMC6657624
IF 2.394
引用数 2
リソース情報
ヒト・動物細胞 PC-12(RCB0009)