論文 - 詳細
RRC ID | 64156 |
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著者 | Chen S, Huang L, Sun K, Wu D, Li M, Li M, Zhong B, Chen M, Zhang S. |
タイトル | Enhancer of zeste homolog 2 as an independent prognostic marker for cancer: a meta-analysis. |
ジャーナル | PLoS One |
Abstract |
BACKGROUND:Novel biomarkers are of particular interest for predicting cancer prognosis. This study aimed to explore the associations between enhancer of zeste homolog 2 (EZH2) and patient survival in various cancers. METHODS:Relevant literature was retrieved from PubMed and Web of Science databases. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. RESULTS:Forty-nine studies (8,050 patients) were included. High EZH2 expression was significantly associated with shorter overall (hazard ratio [HR] 1.74, 95% CI: 1.46-2.07), disease-free (HR 1.59, 95% CI: 1.27-1.99), metastasis-free (HR 2.19, 95% CI: 1.38-3.47), progression-free (HR 2.53, 95% CI: 1.52-4.21), cancer-specific (HR 3.13, 95% CI: 1.70-5.74), and disease-specific (HR 2.29, 95% CI: 1.56-3.35) survival, but not recurrence-free survival (HR 1.38, 95% CI: 0.93-2.06). Moreover, EZH2 expression significantly correlated with distant metastasis (OR 3.25, 95% CI: 1.07-9.87) in esophageal carcinoma; differentiation (OR 3.00, 95% CI: 1.37-6.55) in non-small cell lung cancer; TNM stage (OR 3.18, 95% CI: 2.49-4.08) in renal cell carcinoma; and histological grade (OR 4.50, 95% CI: 3.33-6.09), estrogen receptor status (OR 0.15, 95% CI: 0.11-0.20) and progesterone receptor status (OR 0.30, 95% CI: 0.23-0.39) in breast cancer. CONCLUSIONS:Our results suggested that EZH2 might be an independent prognostic factor for multiple survival measures in different cancers. |
巻・号 | 10(5) |
ページ | e0125480 |
公開日 | 2015-1-1 |
DOI | 10.1371/journal.pone.0125480 |
PII | PONE-D-14-35914 |
PMID | 25974088 |
PMC | PMC4431777 |
MeSH | Biomarkers, Tumor / metabolism* Databases, Factual Disease Progression Enhancer of Zeste Homolog 2 Protein Humans Neoplasms / metabolism Neoplasms / pathology* Odds Ratio Polycomb Repressive Complex 2 / metabolism* |
IF | 2.74 |
リソース情報 | |
ヒト・動物細胞 | RERF-LC-KJ(RCB1313) LC-2/ad(RCB0440) |