論文 - 詳細
| RRC ID | 6427 |
|---|---|
| 著者 | Patel MR, Shen K. |
| タイトル | RSY-1 is a local inhibitor of presynaptic assembly in C. elegans. |
| ジャーナル | Science |
| Abstract |
As fundamental units of neuronal communication, chemical synapses are composed of presynaptic and postsynaptic specializations that form at specific locations with defined shape and size. Synaptic assembly must be tightly regulated to prevent overgrowth of the synapse size and number, but the molecular mechanisms that inhibit synapse assembly are poorly understood. We identified regulator of synaptogenesis-1 (RSY-1) as an evolutionarily conserved molecule that locally antagonized presynaptic assembly. The loss of RSY-1 in Caenorhabditis elegans led to formation of extra synapses and recruitment of excessive synaptic material to presynaptic sites. RSY-1 directly interacted with and negatively regulated SYD-2/liprin-alpha, a master assembly molecule that recruits numerous synaptic components to presynaptic sites. RSY-1 also bound and regulated SYD-1, a synaptic protein required for proper functioning of SYD-2. Thus, local inhibitory mechanisms govern synapse formation. |
| 巻・号 | 323(5920) |
| ページ | 1500-3 |
| 公開日 | 2009-3-13 |
| DOI | 10.1126/science.1169025 |
| PII | 323/5920/1500 |
| PMID | 19286562 |
| PMC | PMC3087376 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / metabolism Cell Line Cell Nucleus / metabolism Humans Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins Mutation Nerve Tissue Proteins / metabolism Nuclear Proteins / chemistry Nuclear Proteins / genetics Nuclear Proteins / metabolism* Phosphoproteins / genetics Phosphoproteins / metabolism Protein Binding Protein Interaction Mapping Protein Isoforms / chemistry Protein Isoforms / genetics Protein Isoforms / metabolism Protein Structure, Tertiary Recombinant Fusion Proteins / metabolism Synapses / metabolism Synapses / physiology* |
| IF | 41.846 |
| 引用数 | 30 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| 線虫 | tm1233 |