| RRC ID |
64578
|
| 著者 |
Vong K, Tahara T, Urano S, Nasibullin I, Tsubokura K, Nakao Y, Kurbangalieva A, Onoe H, Watanabe Y, Tanaka K.
|
| タイトル |
Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy.
|
| ジャーナル |
Sci Adv
|
| Abstract |
This study presents the early framework of selective cell tagging (SeCT) therapy, which is the concept of preferentially labeling specific cells in vivo with chemical moieties that can elicit a therapeutic response. Using glycosylated artificial metalloenzyme (GArM)-based protein labeling, this study reports two separate functional strategies. In one approach, early tumor onset can be suppressed by tagging cancer cells in living mice with an integrin-blocking cyclic-Arg-Gly-Asp (cRGD) moiety, thereby disrupting cell adhesion onto the extracellular matrix. In another approach, tumor growth in mice can be reduced by tagging with a cytotoxic doxorubicin moiety. Subsequent cell death occurs following internalization and drug release. Overall, experiments have shown that mouse populations receiving the mixture of SeCT labeling reagents exhibited a significant delay/reduction in tumor onset and growth compared with controls. Highlighting its adaptability, this work represents a foundational step for further development of SeCT therapy and its potential therapeutic applications.
|
| 巻・号 |
7(17)
|
| 公開日 |
2021-4-1
|
| DOI |
10.1126/sciadv.abg4038
|
| PII |
7/17/eabg4038
|
| PMID |
33893089
|
| PMC |
PMC8064634
|
| IF |
13.117
|
| リソース情報 |
| ヒト・動物細胞 |
HeLa(RCB0007) |
