RRC ID 70822
Author Ryan SM, Almassey M, Burch AM, Ngo G, Martin JM, Myers D, Compton D, Archie S, Cross M, Naeger L, Salzman A, Virola-Iarussi A, Barbee SA, Mortimer NT, Sanyal S, Vrailas-Mortimer AD.
Title Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis.
Journal Aging Cell
Abstract As organisms age, they often accumulate protein aggregates that are thought to be toxic, potentially leading to age-related diseases. This accumulation of protein aggregates is partially attributed to a failure to maintain protein homeostasis. A variety of genetic factors have been linked to longevity, but how these factors also contribute to protein homeostasis is not completely understood. In order to understand the relationship between aging and protein aggregation, we tested how a gene that regulates lifespan and age-dependent locomotor behaviors, p38 MAPK (p38Kb), influences protein homeostasis as an organism ages. We find that p38Kb regulates age-dependent protein aggregation through an interaction with starvin, a regulator of muscle protein homeostasis. Furthermore, we have identified Lamin as an age-dependent target of p38Kb and starvin.
Volume 20(11)
Pages e13481
Published 2021-11-1
DOI 10.1111/acel.13481
PMID 34674371
PMC PMC8590102
MeSH Aging / genetics Aging / metabolism* Animals Animals, Genetically Modified Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Female Gene Deletion Lamins / metabolism Locomotion / genetics Longevity / genetics* MAP Kinase Signaling System / genetics* Macroautophagy / genetics Muscles / metabolism Oxidative Stress / genetics Phenotype Proteolysis Proteostasis / genetics* RNA Interference p38 Mitogen-Activated Protein Kinases / genetics p38 Mitogen-Activated Protein Kinases / metabolism*
IF 7.238
Drosophila DGRC#115622 DGRC#115336