RRC ID 70845
著者 Bajgiran M, Azlan A, Shamsuddin S, Azzam G, Halim MA.
タイトル Data on RNA-seq analysis of Drosophila melanogaster during ageing.
ジャーナル Data Brief
Abstract Ageing is defined as gradual decline of physiological, cellular and molecular state of an organism with time. The age-associated cell dysfunctions usually cause chronic diseases such as diabetes, cancers and other age-related diseases. Many of the genes and pathways involved in ageing are conserved in different species. These genes and pathways have been categorised into nine cellular and molecular hallmarks, namely, genomic instability, telomere attrition, loss of proteostasis, mitochondrial dysfunction, epigenetic alterations, deregulated nutrient sensing, stem cell exhaustion, cellular senescence and altered intercellular communication. Despite countless studies on ageing, the molecular mechanism of ageing is poorly understood. Here, we performed genome wide transcriptome mapping of ageing process in D. melanogaster. In which, transcriptomic analysis conducted on the 1 day and 60 days flies. Illumina Hiseq platform were used to generate raw data. Afterwards, further analysis including differential expression analysis, GO classification and KEGG pathway enrichment analysis were performed. The raw data were uploaded to SRA database and the BioProject ID is PRJNA718442. These data provide the basis for future research in order to discover the genes and pathways involved in ageing.
巻・号 38
ページ 107413
公開日 2021-10-1
DOI 10.1016/j.dib.2021.107413
PII S2352-3409(21)00695-8
PMID 34632013
PMC PMC8488473
リソース情報
ショウジョウバエ DGRC#107294