| Abstract |
The number of people with diabetes worldwide has increased to 537 million, with a 3.6-fold increase occurring in the last 20 years. Various medications are used in the treatment of diabetes, and glucagon-like peptide-1 (GLP-1) receptor agonists have been recommended in major overseas guidelines. Although the main route of administration of GLP-1 receptor agonists is subcutaneous, orally administered GLP-1 receptor agonists were approved in 2019. Therefore, gastrointestinal epithelial cells are exposed to GLP-1 receptor agonists with poor bioavailability; however, it currently remains unclear whether this luminal approach damages these cells. The present study investigated the effects of GLP-1 receptor agonists on gastrointestinal epithelial cells. The gastrointestinal epithelial cell lines HGC-27, IEC-6, and Caco-2 were treated with Liraglutide, a GLP-1 receptor agonist. The protein expression of the GLP-1 receptor was confirmed in these cell lines, and Liraglutide did not significantly affect their proliferation. Although no inhibitory effects on oxidative stress were noted, Liraglutide appeared to alter the expression of drug absorption-regulating factors. In conclusion, since no significant changes were detected in the cell lines examined, even at higher concentrations of Liraglutide, there were no significant effects at the cellular level. However, since the present results were contradictory to previous findings, further studies using different conditions and cells are warranted.
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