RRC ID 73043
Author Nagahata Y, Masuda K, Nishimura Y, Ikawa T, Kawaoka S, Kitawaki T, Nanya Y, Ogawa S, Suga H, Satou Y, Takaori-Kondo A, Kawamoto H.
Title Tracing the evolutionary history of blood cells to the unicellular ancestor of animals.
Journal Blood
Abstract Blood cells are thought to have emerged as phagocytes in the common ancestor of animals followed by the appearance of novel blood cell lineages such as thrombocytes, erythrocytes, and lymphocytes, during evolution. However, this speculation is not based on genetic evidences and it is still possible to argue that phagocytes in different species have different origins. It also remains to be clarified how the initial blood cells evolved: whether ancient animals have solely developed de novo programs for phagocytes, or they have inherited a key program from ancestral unicellular organisms. Here we traced the evolutionary history of blood cells, and cross-species comparison of gene expression profiles revealed that phagocytes in various animal species and Capsaspora, a unicellular organism, are transcriptionally similar to each other. We also found that both phagocytes and Capsaspora share a common phagocytic program, and that CEBPa is the sole transcription factor highly expressed in both phagocytes and Capsaspora. We further showed that the function of CEBPa to drive phagocyte program in non-phagocytic blood cells has been conserved in tunicate, sponge and Capsaspora. We finally showed that, in murine hematopoiesis, repression of CEBPa to maintain non-phagocytic lineages is commonly achieved by polycomb complex. These findings indicate that the initial blood cells emerged inheriting a unicellular organism program driven by CEBPa and that the program has been also seamlessly inherited in phagocytes of various animal species throughout evolution.
Published 2022-9-16
DOI 10.1182/blood.2022016286
PII 486649
PMID 36112959
IF 17.794
C.intestinalis / (O.japonicus) Ciona intestinalis (C. robusta) wild type