RRC ID |
81349
|
Author |
Akter R, Kirkwood N, Zaman S, Lu B, Wang T, Takakusagi S, Mulvaney P, Biju V, Takano Y.
|
Title |
Bio-catalytic nanoparticle shaping for preparing mesoscopic assemblies of semiconductor quantum dots and organic molecules.
|
Journal |
Nanoscale Horiz
|
Abstract |
We report a unique bio-catalytic nanoparticle shaping (BNS) method for preparing a variety of mesoscopic particles by a facile process. For example, the BNS method affords mesoscopic QD assembly dispersions. Large-size sedimentations (>1 μm) of QDs are first formed using oligo-L-lysine linkers. These then undergo controlled enzymatic cleavage of the linkers using trypsin, which surprisingly leads to mesoscopic particles about 84 nm in size with a narrow size distribution. A detailed mechanism of the BNS method is investigated using tetrakis(4-carboxyphenyl)porphyrin (TCPP), instead of QDs, as a probe molecule. Interestingly, the BNS method can also be applied to other combinations of enzymes and enzymatically degradable linkers, such as hyaluronidase with hyaluronan. As a potential application, the mesoscopic particles of QDs and oligo-lysine exhibit their ability to act as a drug delivery carrier originating from the features of both QDs and oligo-lysine. The BNS method demonstrates the universality and versatility of preparing mesoscopic particles and opens new doors for studying QD assemblies and molecular-based mesoscopic particles.
|
Volume |
9(7)
|
Pages |
1128-1136
|
Published |
2024-6-24
|
DOI |
10.1039/d4nh00134f
|
PMID |
38780444
|
Resource |
Human and Animal Cells |
HeLa(RCB0007) |