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  • Search Condition : Filter (MeSH = Adaptor Proteins, Signal Transducing / metabolism*)
Species Resource
Pathogenic microorganisms NA Shigella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery.
C.elegans tm1031 The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans.
C.elegans tm1137 The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.
Mice Nrf2 knockout mouse/C57BL6J(RBRC01390) Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
DNA material pRx nZ ires Neo (RDB01699). Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.
Arabidopsis / Cultured plant cells, genes pda08829 The Arabidopsis adaptor protein AP-3μ interacts with the G-protein β subunit AGB1 and is involved in abscisic acid regulation of germination and post-germination development.
Drosophila 11107R-2 The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.
DNA material pco12 EGFR (RDB01276) , CSII-EF-MCS (RDB04378). ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
Mice Emx1-Cre KI Δneo(RBRC01345) JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration.
DNA material , Xenopus tropicalis RDB6727 X. laevis whole embryo(stage 10.5) EST clones (XL151H21) The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin.
Mice C57BL/6・129 SH2-B -/-(RBRC00994) SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload.
DNA material CS-CDF-CG-PRE (RDB04379) , pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) Knockdown of synapse-associated protein Dlg1 reduces syncytium formation induced by human T-cell leukemia virus type 1.
DNA material pEF-DEST51_mm Pdlim5 (RDB13418) , pEF-DEST51_mm S177A Pdlim5 (RDB13419) , pEF-DEST51_mm S177D Pdlim5 (RDB13420) , pGEX6.1_mm Pdlim5 (RDB13421) , pGEX6.1_mm S177A Pdlim5 (RDB13422) , pGEX6.1_mm S177D Pdlim5 (RDB13423). Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.
Drosophila Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment.
Human and Animal Cells Interaction of Keap1 modified by 2-tert-butyl-1,4-benzoquinone with GSH: evidence for S-transarylation.
Human and Animal Cells The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling.
Human and Animal Cells Association of p62/SQSTM1 excess and oral carcinogenesis.
Human and Animal Cells Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.
Human and Animal Cells TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy.
Human and Animal Cells PRAS40 is a functionally critical target for EWS repression in Ewing sarcoma.