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論文 - 一覧

  • 11 Hits
  • 検索条件 : 絞込み (MeSH = Amyloid Precursor Protein Secretases / metabolism*)
生物種 リソース名 タイトル
遺伝子材料 Alcadein a-FLAG /pcDNA3.1(+) (RDB19587) , Alcadein b-FLAG /pcDNA3.1(+) (RDB19588) , Alcadein g-FLAG /pcDNA3.1(+) (RDB19589) Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
ヒト・動物細胞 C2C12(RCB0987) , 10T1/2(RCB0247) Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner.
実験動物マウス RBRC02192 P38α-MAPK phosphorylates Snapin and reduces Snapin-mediated BACE1 transportation in APP-transgenic mice.
ヒト・動物細胞 HPB-ALL(RCB1935) The Notch inhibitor cowanin accelerates nicastrin degradation.
ヒト・動物細胞 GM95(RCB1026) , MEB4(RCB1027) Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity.
実験動物マウス RBRC02192 Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.
線虫 tm6062 A γ-Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans.
遺伝子材料 Human ILEI / pcDNA6 (RDB13040) , Human ILEI-siRNA / pSUP (RDB13041). The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.
シロイヌナズナ / 植物培養細胞・遺伝子 pda05311 , pda05606 , pda11696 , pda12309 Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana.
ショウジョウバエ 4591R-1 , 4591R-2 TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals.
ヒト・動物細胞 B16 melanoma(RCB1283) , GM95(RCB1026) Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.