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  • Search Condition : Filter (MeSH = Amyloid Precursor Protein Secretases / metabolism*)
Species Resource Title
DNA material Alcadein a-FLAG /pcDNA3.1(+) (RDB19587) , Alcadein b-FLAG /pcDNA3.1(+) (RDB19588) , Alcadein g-FLAG /pcDNA3.1(+) (RDB19589) Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
Human and Animal Cells C2C12(RCB0987) , 10T1/2(RCB0247) Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner.
Mice RBRC02192 P38α-MAPK phosphorylates Snapin and reduces Snapin-mediated BACE1 transportation in APP-transgenic mice.
Human and Animal Cells HPB-ALL(RCB1935) The Notch inhibitor cowanin accelerates nicastrin degradation.
Human and Animal Cells GM95(RCB1026) , MEB4(RCB1027) Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity.
Mice RBRC02192 Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.
C.elegans tm6062 A γ-Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans.
DNA material Human ILEI / pcDNA6 (RDB13040) , Human ILEI-siRNA / pSUP (RDB13041). The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.
Arabidopsis / Cultured plant cells, genes pda05311 , pda05606 , pda11696 , pda12309 Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana.
Drosophila 4591R-1 , 4591R-2 TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals.
Human and Animal Cells B16 melanoma(RCB1283) , GM95(RCB1026) Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.