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  • Search Condition : Filter (MeSH = Diphosphonates / pharmacology*)
Species Resource Title
Human and Animal Cells LM8(RCB1450) Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway.
Human and Animal Cells PC-9(RCB4455) Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells.
Human and Animal Cells NIH/3T3(RCB2767) Zoledronic acid suppresses transforming growth factor-β-induced fibrogenesis by human gingival fibroblasts.
Human and Animal Cells HL60(RCB0041) , U-937 DE-4(RCB0435) Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.
Human and Animal Cells TGBC1TKB(RCB1129) , TGBC24TKB(RCB1196) Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid.
Human and Animal Cells ST2(RCB0224) Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2.
Human and Animal Cells MC3T3-E1(RCB1126) , Saos2 , NIH3T3-3 , 10T1/2(RCB0247) Suppressive effects of N-bisphosphonate in osteoblastic cells mitigated by non-N-bisphosphonate but not by sodium-dependent phosphate cotransporter inhibitor.
Human and Animal Cells J774.1(RCB0434) MPMBP down-regulates Toll-like receptor (TLR) 2 ligand-induced proinflammatory cytokine production by inhibiting NF-κB but not AP-1 activation.
Human and Animal Cells Li-7(RCB1941) , Hep G2(RCB1648) , T2(RCB1932) , K562 Hepatocellular carcinoma cell sensitivity to Vγ9Vδ2 T lymphocyte-mediated killing is increased by zoledronate.
Medaka rankl:HSE:CFP (TG1135) , ctsk:nlGFP (TG1132) , rankl:HSE:CFP/ctsk:nlGFP (TG1139) , osx:mCherry (TG1134) Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model.
Human and Animal Cells MG‐63(RCB1890) The inhibitory effect of bisphosphonates on glucocorticoid-induced RANKL expression in human cells.
Human and Animal Cells A new bisphosphonate, YM529 induces apoptosis in HL60 cells by decreasing phosphorylation of single survival signal ERK.
Human and Animal Cells HL60(RCB0041) , Jurkat(RCB0806) , K562 , MOLT-4(RCB0206) , U-937 DE-4(RCB0435) Apoptosis-inducing effect of a new bisphosphonate, YM529, on various hematopoietic tumor cell lines.
Human and Animal Cells ST2(RCB0224) , MC3T3-G2/PA6(RCB1127) A third-generation bisphosphonate, YM175, inhibits osteoclast formation in murine cocultures by inhibiting proliferation of precursor cells via supporting cell-dependent mechanisms.
Human and Animal Cells RAW 264(RCB0535) Evaluation of pharmaceuticals with a novel 50-hour animal model of bone loss.
Human and Animal Cells ST2(RCB0224) , MLC-6(RCB1536) Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells.