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論文 - 一覧

  • 22 Hits
  • 検索条件 : 絞込み (MeSH = Drug Design*)
生物種 リソース名 タイトル
ヒト・動物細胞 RAW 264(RCB0535) Designing an anti-inflammatory and tissue-adhesive colloidal dressing for wound treatment.
ヒト・動物細胞 MKN74(RCB1002) , DU145(RCB2143) , PC-3(RCB2145) Synthesis and biological evaluation of new rhodanine analogues bearing 2-chloroquinoline and benzo[h]quinoline scaffolds as anticancer agents.
ヒト・動物細胞 PC-9(RCB4455) Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
ヒト・動物細胞 PC-9(RCB4455) Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.
ヒト・動物細胞 A549(RCB0098) Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2.
ヒト・動物細胞 MKN45(RCB1001) Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4′-piperidine]-2-ones as potential c-Met inhibitors
ヒト・動物細胞 MCF7(RCB1904) , A549(RCB0098) Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.
ヒト・動物細胞 HeLa(RCB0007) Design and synthesis of temperature-responsive polymer/silica hybrid nanoparticles and application to thermally controlled cellular uptake.
ヒト・動物細胞 NCC-RbC-51(RCB2206) Designing and enhancing the antifungal activity of corneal specific cell penetrating peptide using gelatin hydrogel delivery system.
ヒト・動物細胞 A549(RCB0098) , MCF7(RCB1904) Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity.
ヒト・動物細胞 NIH:OVCAR-3(RCB2135) , HeLa(RCB0007) A novel Golgi mannosidase inhibitor: Molecular design, synthesis, enzyme inhibition, and inhibition of spheroid formation.
ヒト・動物細胞 MKN1(RCB1003) Rational design of small molecule RHOA inhibitors for gastric cancer.
ヒト・動物細胞 HeLa(RCB0007) Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery.
ヒト・動物細胞 Ba/F3(RCB0805) , A431 Generation of an anti-desmoglein 3 antibody without pathogenic activity of pemphigus vulgaris for therapeutic application to squamous cell carcinoma.
一般微生物 JCM 20379 Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening.
実験動物マウス RBRC00806 ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice.
病原微生物 Target validation and ligand development for a pathogenic fungal profilin, using a knock-down strain of pathogenic yeast Candida glabrata and structure-based ligand design.
ヒト・動物細胞 Colon-26(RCB2657) Design and evaluation of thioalkylated mannose-modified dendrimer (G3)/α-cyclodextrin conjugates as antigen-presenting cell-selective siRNA carriers.
ヒト・動物細胞 Indazoles as potential c-Met inhibitors: design, synthesis and molecular docking studies.
ヒト・動物細胞 MCF7(RCB1904) Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.