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  • Search Condition : Filter (MeSH = Guanine Nucleotide Exchange Factors / metabolism*)
Species Resource Title
DNA material pcDNA3-HA-GBF1 (RDB20111) , pcDNA3-HA-GBF1(E794K) (RDB20112) , pcDNA4-Xpress-GBF1 (RDB20113) , pcDNA4-Xpress-GBF1(E794K) (RDB20114) GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat.
Human and Animal Cells LY-A(RCB1869) , LY-A/hCERT(RCB1870) Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development.
C.elegans tm3203 The Integrin Signaling Network Promotes Axon Regeneration via the Src-Ephexin-RhoA GTPase Signaling Axis.
DNA material C-Epac2-Y (RDB19602) The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs.
Human and Animal Cells Lu99(RCB1900) , PC-9(RCB4455) Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.
Lotus / Glycine pUB-GWS-GFP , pUB-GFP SPIKE1 Activates the GTPase ROP6 to Guide the Polarized Growth of Infection Threads in Lotus japonicus.
Drosophila The Clathrin adaptor AP-1 and Stratum act in parallel pathways to control Notch activation in Drosophila sensory organ precursors cells.
Human and Animal Cells ATDC5(RCB0565) Prostacyclin regulates bone growth via the Epac/Rap1 pathway.
DNA material pMRX-puro-EGFP-FLCN (RDB17951) , pMRX-puro-EGFP-DENND1A (RDB17952) , pMRX-puro-EGFP-DENND1B (RDB17953) , pMRX-puro-EGFP-DENND1C (RDB17954) Rab35-GEFs, DENND1A and folliculin differentially regulate podocalyxin trafficking in two- and three-dimensional epithelial cell cultures.
Arabidopsis / Cultured plant cells, genes pda Interactions between Transport Protein Particle (TRAPP) complexes and Rab GTPases in Arabidopsis.
C.elegans tm5597 Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub.
Human and Animal Cells 293T(RCB2202) Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration.
C.elegans tm920 miR-51 regulates GABAergic synapses by targeting Rab GEF GLO-4 and lysosomal trafficking-related GLO/AP-3 pathway in Caenorhabditis elegans.
C.elegans tm1095 , tm2807 RPM-1 and DLK-1 regulate pioneer axon outgrowth by controlling Wnt signaling.
Human and Animal Cells COS-7(RCB0539) Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells.
DNA material pEF-T7-mALS2 (RDB17219) , pEF-T7-mALS2-D1593A (RDB17220). Rab5 activation on macropinosomes requires ALS2, and subsequent Rab5 inactivation through ALS2 detachment requires active Rab7.
C.elegans tm4024 , tm9033 , tm2143 , tm2409 , tm2241 , tm3310 DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans.
Cellular slime molds G90307 The F-actin-binding RapGEF GflB is required for efficient macropinocytosis in Dictyostelium.
DNA material pEGFP-C1-human DENN (RDB15288) , pEGFP-C1-mouse DENND1A (RDB15289) , pEGFP-C1-mouse DENND3 (RDB15290). MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.
DNA material pcDNA4c/His-Xpress-HA-hBIG2(WT) (RDB15364) , pcDNA4c/His-Xpress-HA-hBIG2(E738K) (RDB15365). Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.