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  • Search Condition : Filter (MeSH = Histone Demethylases / metabolism*)
Species Resource Title
C.elegans tm2176 , tm2181 Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
C.elegans tm3118 , tm3735 , tm2828 , tm2966 , tm3121 , tm3197 , tm1200 Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality.
Human and Animal Cells TLR2(RCB0750) PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B.
Human and Animal Cells MCF7(RCB1904) , 293T(RCB2202) SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.
Drosophila DGRC#104754 A KDM5-Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation.
Human and Animal Cells ATDC5(RCB0565) , 10T1/2(RCB0247) Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity.
Drosophila Drosophila Histone Demethylase KDM4A Has Enzymatic and Non-enzymatic Roles in Controlling Heterochromatin Integrity.
C.elegans tm2469 HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.
C.elegans tm3118 The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner.
C.elegans tm3118 Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.
C.elegans tm1905 Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation.
C.elegans tm1231 H3K4 demethylase activities repress proliferative and postmitotic aging.
Human and Animal Cells A549 , RERF-LC-AI(RCB0444) The histone demethylase PHF8 is an oncogenic protein in human non-small cell lung cancer.
Human and Animal Cells 293(RCB1637) Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2).
DNA material CSII-CMV-MCS-IRES2-Bsd (RDB04385) Clinical Significance of Histone Demethylase NO66 in Invasive Colorectal Cancer.
Human and Animal Cells TE-1(RCB1894) , TE-4(RCB2097) , TE-6(RCB1950) , TE-10(RCB2099) , TE-14(RCB2101) , TE-15(RCB1951) Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer.
Human and Animal Cells MC3T3-E1(RCB1126) Histone demethylase Utx regulates differentiation and mineralization in osteoblasts.
DNA material Genome Network Project cDNA Clone IRAL018B15 (HGY087239) , pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393). LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling the Expression of a Novel Target Gene, HEYL.
Drosophila NP0618 (DGRC#103678) and the HP1a alleles Su(var)2–5 04 and Su(var)2–5 05 and others Gene regulation by the lysine demethylase KDM4A in Drosophila.