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  • Search Condition : Filter (MeSH = Huntington Disease / metabolism*)
Species Resource Title
C.elegans tm1108 Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation.
Drosophila 11144R-3 Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.
Drosophila Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.
Drosophila Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease.
C.elegans tm4397 The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease.
Drosophila 7563R-1 , 18152R-2 Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.
Mice RBRC00806 The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
Drosophila 7459R-2 Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding.
C.elegans fust-1(tm4439) , pgrn-1(tm985) Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.
Mice RBRC00806 A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.
C.elegans tm1374 Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.