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  • Search Condition : Filter (MeSH = Longevity / genetics*)
Species Resource Title
C.elegans tm4397 , tm4212 ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1.
C.elegans tm3391 Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans.
C.elegans tm1563 Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1.
C.elegans tm6369 Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans.
Drosophila DGRC#115622 , DGRC#115336 Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis.
C.elegans tm5007 , tm3121 , tm3197 , tm3118 H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
C.elegans tm5030 , tm6659 Mutation of daf-2 extends lifespan via tissue-specific effectors that suppress distinct life-limiting pathologies.
C.elegans tm1231 Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids.
Drosophila DGRC#112001 Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila.
Drosophila DGRC#142168 Loss of CNDP causes a shorter lifespan and higher sensitivity to oxidative stress in Drosophila melanogaster.
C.elegans tm4687 A fln-2 mutation affects lethal pathology and lifespan in C. elegans.
C.elegans tm5159 , tm1556 , tm1447 A hormone receptor pathway cell-autonomously delays neuron morphological aging by suppressing endocytosis.
C.elegans tm1978 Lifespan Extension in C. elegans Caused by Bacterial Colonization of the Intestine and Subsequent Activation of an Innate Immune Response.
C.elegans tm783 , tm760 , tm1146 Resistance to Stress Can Be Experimentally Dissociated From Longevity.
C.elegans tm1452 The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity.
C.elegans tm760 , tm4525 Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.
C.elegans tm1714 , tm3759 , tm3510 Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans.
Drosophila DGRC#108069 Apoptosis inhibition mitigates aging effects in Drosophila melanogaster.
Drosophila DGRC#110626 Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity.
Drosophila The role of DNA repair genes in radiation-induced adaptive response in Drosophila melanogaster is differential and conditional.