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  • Search Condition : Filter (MeSH = Lysosomes / metabolism*)
Species Resource Title
Human and Animal Cells THP-1(RCB1189) The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation.
C.elegans tm3425 Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans.
DNA material pMRX-IP-GFP-STX17 (RDB19636) , pMRX-IP-GFP-SNAP29 (RDB19638) , pMRX-IP-GFP-VAMP7 (RDB19639) , pMRX-IP-GFP-VAMP8 (RDB19640) , p3xFLAG-CMV10-Stx17 (RDB19761) , p3xFLAG-CMV10-SNAP29 (RDB19765) , p3xFLAG-CMV10-VAMP7 (RDB19778) , pMRXIP GFP-Stx7 (RDB19779) , pMRXIP-GFP-Stx18 (RDB19792) , pMRXIP-GFP-Stx17TM (RDB19793) The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.
Zebrafish Tg(vglut2a:loxP-DsRed-loxP-GFP) G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Human and Animal Cells 201B7(HPS0063) Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.
DNA material pMRX-puro-FLAG-hVPS52 (RDB18998) , pMRX-puro-FLAG-hVPS52_N670 (RDB18999) , pMRX-puro-FLAG-hVPS52_N556 (RDB19000) , pMRX-puro-FLAG-hVPS52_N410 (RDB19001) , pMRX-bsr-ss-sfGFP (RDB19002) Knockout analysis of Rab6 effector proteins revealed the role of VPS52 in the secretory pathway.
Human and Animal Cells KP4(RCB1005) , PK-1(RCB1972) Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
C.elegans tm1108 , tm1978 Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) , RAW 264(RCB0535) Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88.
Human and Animal Cells HuH-7(RCB1366) , CHO-K1(RCB0285) Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1.
Human and Animal Cells IMR-90-SV(RCB1024) , Rat-1(RCB1830) Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy.
DNA material pMRX-IP TFEB-sfGFP (RDB18607) , pCW DNAseIIα-sfGFP-T2A-mCherry (RDB18608) Identification of a factor controlling lysosomal homeostasis using a novel lysosomal trafficking probe.
Human and Animal Cells Atg5^(-/-)MEF(RCB2711) Sucrose induces vesicle accumulation and autophagy.
Human and Animal Cells ST2(RCB0224) Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.
Drosophila 5520R-1 , 18255R-1 , 31014R-2 , 9726R-1 , 31015R-1 Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity.
Drosophila 31935R-3 The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 Complex I.
DNA material SRAI_pcDNA3 (RDB18222) , mito-SRAI_pcDNA3 (RDB18223) , pAAV2-TRE-mito-SRAI-BGHpA (RDB18684) , pAAV2-SYN-tTAad-BGHpA (RDB18685) Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration.
C.elegans tm3425 , tm2508 The RBG-1-RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans.
C.elegans tm1978 , tm4324 , tm1974 , tm1954 , tm4498 , tm4417 Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival.