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  • 8 Hits
  • Search Condition : Filter (MeSH = Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors*)
Species Resource Title
Human and Animal Cells OS-RC-2(RCB0735) , TUHR10TKB(RCB1275) , TUHR14TKB(RCB1383) Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells.
Human and Animal Cells HuH-7 Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer.
Human and Animal Cells OMC-3(RCB0755) , JHOC-5(RCB1520) KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer.
Human and Animal Cells MIA Paca2(RCB2094) , KP4(RCB1005) , PK-45 , PK-59(RCB1901) MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth.
Human and Animal Cells Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells.
Human and Animal Cells MC3T3-E1(RCB1126) , C2C12(RCB0987) Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix.
Human and Animal Cells Inhibition of MEK/ERK signaling induces apoptosis of acute myelogenous leukemia cells via inhibition of eukaryotic initiation factor 4E-binding protein 1 and down-regulation of Mcl-1.
Human and Animal Cells LM8(RCB1450) Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma.