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  • Search Condition : Filter (MeSH = Neurodegenerative Diseases / metabolism*)
Species Resource Title
Human and Animal Cells ASF-4-3L(RCB3580) A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes.
C.elegans tm1779 Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases.
Human and Animal Cells U251(RCB0461) Expression of alpha-synuclein in a human glioma cell line and its up-regulation by interleukin-1beta.
Drosophila 2155R-2 , 3757R-5 , 8221R-4 , 8221R-1 Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging.
Mice RBRC06334 Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases.
Human and Animal Cells KG-1-C(RCB0270) Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.
Drosophila Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.
C.elegans tm1153 Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.
Human and Animal Cells HPS1046 SLC20A2 variants cause dysfunctional phosphate transport activity in endothelial cells induced from Idiopathic Basal Ganglia Calcification patients-derived iPSCs.
C.elegans tm4909 Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.
C.elegans tm1325 , tm1548 Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans.
Mice RBRC01345 Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice.
Drosophila DGRC#105467 A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline.
Drosophila 13387R-1 , 13387R-4 Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.
Drosophila Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones.
Drosophila DGRC#200507 Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration.
Drosophila Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila.
Drosophila Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.
Drosophila Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration.