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  • 62 Hits
  • Search Condition : Filter (MeSH = Phosphatidylinositol 3-Kinases / metabolism*)
Species Resource
Human and Animal Cells HSC-3(RCB1975) DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways.
Human and Animal Cells TKKK(RCB1907) , TGBC24TKB(RCB1196) , HuCCT1(RCB1960) PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay.
Human and Animal Cells ATDC5(RCB0565) Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis.
Human and Animal Cells CACO-2(RCB0988) Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.
Human and Animal Cells MKN1(RCB1003) Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer.
C.elegans tm1888 Insulin/IGF-1 signaling, including class II/III PI3Ks, β-arrestin and SGK-1, is required in C. elegans to maintain pharyngeal muscle performance during starvation.
C.elegans tm4475 PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.
Human and Animal Cells The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL.
Human and Animal Cells Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.
Human and Animal Cells Cigarette sidestream smoke induces histone H3 phosphorylation via JNK and PI3K/Akt pathways, leading to the expression of proto-oncogenes.
Human and Animal Cells Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
Human and Animal Cells PI3K pathway dependencies in endometrioid endometrial cancer cell lines.
Human and Animal Cells Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis.
Human and Animal Cells Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk.
Human and Animal Cells Insulin-like growth factor (IGF)-II regulates CCAAT/enhancer binding protein alpha expression via phosphatidyl-inositol 3 kinase in human hepatoblastoma cell lines.
Human and Animal Cells Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines.
Human and Animal Cells Parathyroid hormone activates phosphoinositide 3-kinase-Akt-Bad cascade in osteoblast-like cells.
Human and Animal Cells Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts.
Human and Animal Cells Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone.
Human and Animal Cells Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2.