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  • 69 Hits
  • Search Condition : Filter (MeSH = Phosphatidylinositol 3-Kinases / metabolism*)
Species Resource Title
Human and Animal Cells ATDC5(RCB0565) Involvement of the phosphoinositide 3-kinase/protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5.
Human and Animal Cells A172(RCB2530) Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.
Human and Animal Cells HeLa(RCB0007) , Saos-2(RCB0428) Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Human and Animal Cells MCF7(RCB1904), L929 GANT61 and curcumin-loaded PLGA nanoparticles for GLI1 and PI3K/Akt-mediated inhibition in breast adenocarcinoma.
Human and Animal Cells MC3T3-E1(RCB1126) BMP9 directly induces rapid GSK3-β phosphorylation in a Wnt-independent manner through class I PI3K-Akt axis in osteoblasts.
Cellular slime molds Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells.
Human and Animal Cells HSC-3(RCB1975) DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways.
Human and Animal Cells TKKK(RCB1907) , TGBC24TKB(RCB1196) , HuCCT1(RCB1960) PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay.
Human and Animal Cells ATDC5(RCB0565) Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis.
Human and Animal Cells CACO-2(RCB0988) Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.
Human and Animal Cells MKN1(RCB1003) Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer.
C.elegans tm1888 Insulin/IGF-1 signaling, including class II/III PI3Ks, β-arrestin and SGK-1, is required in C. elegans to maintain pharyngeal muscle performance during starvation.
C.elegans tm4475 PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.
Human and Animal Cells The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL.
Human and Animal Cells Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.
Human and Animal Cells Cigarette sidestream smoke induces histone H3 phosphorylation via JNK and PI3K/Akt pathways, leading to the expression of proto-oncogenes.
Human and Animal Cells Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
Human and Animal Cells PI3K pathway dependencies in endometrioid endometrial cancer cell lines.
Human and Animal Cells Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis.
Human and Animal Cells Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk.