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  • Search Condition : Filter (MeSH = Protein Inhibitors of Activated STAT / metabolism*)
Species Resource
Human and Animal Cells ATDC5(RCB0565) A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.
DNA material pFLAG-FIP1L1-PDGFRA-FL (RDB15460) , pFLAG-FIP1L1-PDGFRA-KD (RDB15461) , pFLAG-PDGFRA-C (RDB15462) , pCGT-FIP1L1-PDGFRA-FL (RDB15463) , pCGT-FIP1L1-PDGFRA-KD (RDB15464) , pCGT-PDGFRAC (RDB15465). Leukemogenic kinase FIP1L1-PDGFRA and a small ubiquitin-like modifier E3 ligase, PIAS1, form a positive cross-talk through their enzymatic activities.
DNA material pRSFlag_mmSumo1 (RDB06126) Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.
Arabidopsis / Cultured plant cells, genes pda10760 The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins.
DNA material pSTAT RE-TK hRluc(F) (RDB05616) , pISRE-TK hRluc(F) (RDB05610) , pGAS RE-TK hRluc(F) (RDB05624). PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts.