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  • 検索条件 : 絞込み (MeSH = Protein Serine-Threonine Kinases / antagonists & inhibitors*)
生物種 リソース名 タイトル
ヒト・動物細胞 EoL-1 cell(RCB0641) p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells.
ヒト・動物細胞 PC-12(RCB0009) Inhibition of the RhoA/Rho kinase system attenuates catecholamine biosynthesis in PC 12 rat pheochromocytoma cells.
ヒト・動物細胞 RAW 264(RCB0535) Piceatannol prevents lipopolysaccharide (LPS)-induced nitric oxide (NO) production and nuclear factor (NF)-kappaB activation by inhibiting IkappaB kinase (IKK).
ヒト・動物細胞 HeLa/Fucci(RCB2812) PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.
ヒト・動物細胞 RERF-LC-AI(RCB0444) A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.
ヒト・動物細胞 Lu99(RCB1900) Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
ヒト・動物細胞 HS-Sch-2(RCB2230) , YST-1(RCB2136) , HS-PSS(RCB2362) Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors.
ヒト・動物細胞 293T(RCB2202) Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
ヒト・動物細胞 C2C12(RCB0987) Rho-kinase as a molecular target for insulin resistance and hypertension.
シロイヌナズナ / 植物培養細胞・遺伝子 rpc00008 Identification of novel compounds that inhibit SnRK2 kinase activity by high-throughput screening.
ヒト・動物細胞 OS-RC-2(RCB0735) , TUHR10TKB(RCB1275) , TUHR14TKB(RCB1383) Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells.
ヒト・動物細胞 NOS-10(RCB2348) , HuO 9N2 (O9N2)(RCB2532) , NOS-1(RCB1032) , HuO-3N1(RCB2104) Direct conversion of osteosarcoma to adipocytes by targeting TNIK.
ヒト・動物細胞 COS-7(RCB0539) Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor.
ヒト・動物細胞 A549(RCB0098) Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells.
線虫 tm2508 Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress.
ショウジョウバエ 10522R-1 , 10522R-2 , DGRC#201488 Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.
ラット WTC.DMY-Mrs2dmy/Kyo (strainID=19) Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats.
ヒト・動物細胞 Y79(RCB1645) , WERI-Rb-1(RCB2146) Inhibition of polo-like kinase 1 promotes hyperthermia sensitivity via inactivation of heat shock transcription factor 1 in human retinoblastoma cells.
ヒト・動物細胞 Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.
ヒト・動物細胞 RERF-LC-KJ(RCB1313) , RERF-LC-AI(RCB0444) , LC-2/ad(RCB0440) , LC-1/sq(RCB0455) , LC-1F(RCB0439) , MS-1(RCB0725) Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules.