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  • 29 Hits
  • Search Condition : Filter (MeSH = Protein Serine-Threonine Kinases / antagonists & inhibitors*)
Species Resource Title
Human and Animal Cells PC-12(RCB0009) Inhibition of the RhoA/Rho kinase system attenuates catecholamine biosynthesis in PC 12 rat pheochromocytoma cells.
Human and Animal Cells RAW 264(RCB0535) Piceatannol prevents lipopolysaccharide (LPS)-induced nitric oxide (NO) production and nuclear factor (NF)-kappaB activation by inhibiting IkappaB kinase (IKK).
Human and Animal Cells HeLa/Fucci(RCB2812) PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.
Human and Animal Cells RERF-LC-AI(RCB0444) A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.
Human and Animal Cells Lu99(RCB1900) Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
Human and Animal Cells HS-Sch-2(RCB2230) , YST-1(RCB2136) , HS-PSS(RCB2362) Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors.
Human and Animal Cells 293T(RCB2202) Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
Human and Animal Cells C2C12(RCB0987) Rho-kinase as a molecular target for insulin resistance and hypertension.
Arabidopsis / Cultured plant cells, genes rpc00008 Identification of novel compounds that inhibit SnRK2 kinase activity by high-throughput screening.
Human and Animal Cells OS-RC-2(RCB0735) , TUHR10TKB(RCB1275) , TUHR14TKB(RCB1383) Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells.
Human and Animal Cells NOS-10(RCB2348) , HuO 9N2 (O9N2)(RCB2532) , NOS-1(RCB1032) , HuO-3N1(RCB2104) Direct conversion of osteosarcoma to adipocytes by targeting TNIK.
Human and Animal Cells COS-7(RCB0539) Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor.
Human and Animal Cells A549(RCB0098) Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells.
C.elegans tm2508 Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress.
Drosophila 10522R-1 , 10522R-2 , DGRC#201488 Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.
Rats WTC.DMY-Mrs2dmy/Kyo (strainID=19) Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats.
Human and Animal Cells Y79(RCB1645) , WERI-Rb-1(RCB2146) Inhibition of polo-like kinase 1 promotes hyperthermia sensitivity via inactivation of heat shock transcription factor 1 in human retinoblastoma cells.
Human and Animal Cells Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.
Human and Animal Cells RERF-LC-KJ(RCB1313) , RERF-LC-AI(RCB0444) , LC-2/ad(RCB0440) , LC-1/sq(RCB0455) , LC-1F(RCB0439) , MS-1(RCB0725) Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules.
Human and Animal Cells Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.