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  • Search Condition : Filter (MeSH = Protein Serine-Threonine Kinases / genetics*)
Species Resource Title
Yeast pNHK53, pMK152 Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.
Pathogenic bacteria V. parahaemolyticus RIMD2210633 Identification of a Family of Vibrio Type III Secretion System Effectors That Contain a Conserved Serine/Threonine Kinase Domain.
Human and Animal Cells JHOS-2(RCB1521) , JHOS-4(RCB1678) , NIH:OVCAR-3(RCB2135) The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma.
Clawed frogs / Newts The dual-specificity protein kinase Clk3 is essential for Xenopus neural development.
DNA material , Human and Animal Cells pCDNA-FLAG-mSIK1 (RDB19160) , pCDNA-FLAG-mSIK1(S577A) (RDB19161) , pCDNA-FLAG-mSIK2 (RDB19162) , pCDNA-FLAG-mSIK2(S587A) (RDB19163) , pCDNA-FLAG-mSIK3 (RDB19164) , pCDNA-FLAG-mSIK3(S551A) (RDB19165) , 293T(RCB2202) Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Human and Animal Cells HTC/C3(RCB0452) Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening.
C.elegans tm1502 PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly.
Human and Animal Cells RBE(RCB1292) , HuH-28(RCB1943) Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma.
Human and Animal Cells HCT116(RCB2979) Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT.
Human and Animal Cells PC-12(RCB0009) High-level expression of the Mnb/Dyrk1A gene in brain and heart during rat early development.
Human and Animal Cells ATDC5(RCB0565) Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
Drosophila 4349R-3 , 4963R-2 Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster.
DNA material pFLAG-mRegnase-1-WT (RDB18148) , pFLAG-mRegnase-1-D141N (RDB18149) , pFLAG-mRegnase-1-KR257258AA (KRAA) (RDB18150) , pFLAG-mRoquin-1-WT (RDB18151) , pmCherry-mRegnase-1-(90-400)-D141N (RDB18152) , pmCherry-mRegnase-1-(130-400)-D141N (RDB18153) , pmRegnase-1-(130-300)-D141N-L2-mCherryX2-C1 (RDB18154) , pmRegnase-1-(3000-400)-L2-mCherryX2-C1 (RDB18155) , pTRE-mIL6CDS-mIL63'UTR (RDB18156) , pGL3-mIL6-3'UTR (RDB18157) , ... Translation-dependent unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs.
C.elegans tm4200 , tm2355 , tm2393 , tm3310 A CCRK and a MAK Kinase Modulate Cilia Branching and Length via Regulation of Axonemal Microtubule Dynamics in Caenorhabditis elegans.
Clawed frogs / Newts Involvement of Myt1 kinase in the G2 phase of the first cell cycle in Xenopus laevis.
Drosophila DGRC#115298 Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis.
Drosophila Loss-of-function mutation in Hippo suppressed enlargement of lysosomes and neurodegeneration caused by dFIG4 knockdown.
Drosophila Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.
C.elegans tm1944 Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence.
DNA material pKM2L-phIL1B (RDB05526) TAZ activation by Hippo pathway dysregulation induces cytokine gene expression and promotes mesothelial cell transformation.