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  • Search Condition : Filter (MeSH = Proto-Oncogene Proteins c-akt / metabolism*)
Species Resource Title
Human and Animal Cells MC3T3-E1(RCB1126) Osteoblasts-derived TGF-beta1 enhance motility and integrin upregulation through Akt, ERK, and NF-kappaB-dependent pathway in human breast cancer cells.
Human and Animal Cells TKKK(RCB1907) , TGBC2TKB(RCB1130) , TGBC18TKB(RCB1169) , TGBC14TKB(RCB1186) , G-415(RCB2640) , HuCCT1(RCB1960) K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.
Human and Animal Cells HeLa(RCB0007) , Saos-2(RCB0428) Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Human and Animal Cells MC3T3-E1(RCB1126) Akt activation is required for TGF-β1-induced osteoblast differentiation of MC3T3-E1 pre-osteoblasts.
Human and Animal Cells MCF7(RCB1904), L929 GANT61 and curcumin-loaded PLGA nanoparticles for GLI1 and PI3K/Akt-mediated inhibition in breast adenocarcinoma.
Human and Animal Cells MC3T3-E1(RCB1126) BMP9 directly induces rapid GSK3-β phosphorylation in a Wnt-independent manner through class I PI3K-Akt axis in osteoblasts.
Human and Animal Cells BALL-1(RCB0256) 3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt.
Human and Animal Cells HSC-3(RCB1975) DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways.
Human and Animal Cells B16 F10(RCB2630) Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3β, and ROS-ERK signaling pathways.
Human and Animal Cells C2C12(RCB0987) Enzymatic digest of whey protein and wheylin-1, a dipeptide released in the digest, increase insulin sensitivity in an Akt phosphorylation-dependent manner.
Human and Animal Cells TE-1(RCB1894) , TE-4(RCB2097) , TE-5(RCB1949) , TE-6(RCB1950) , TE-8(RCB2098) , TE-9(RCB1988) , TE-10(RCB2099) , TE-11(RCB2100) Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.
Human and Animal Cells ATDC5(RCB0565) Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis.
Human and Animal Cells CACO-2(RCB0988) , COLO205(RCB2127) Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.
Human and Animal Cells MG6(RCB2403) Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling.
Human and Animal Cells RERF-LC-AI(RCB0444) , IA-LM(RCB0554) , WA-hT(RCB2279) Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.
C.elegans tm1145 , tm7788 BRAP-2 promotes DNA damage induced germline apoptosis in C. elegans through the regulation of SKN-1 and AKT-1.
C.elegans tm3335 , tm3607 , tm1034 , tm399 , tm1075 , tm1196 Reduced expression of BTBD10, an Akt activator, leads to motor neuron death.
C.elegans tm2313 , tm399 , tm1075 Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway.
Human and Animal Cells The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL.
Human and Animal Cells Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation.